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Biomarkers for microglial activation in Alzheimer's disease.

Journal article
Authors Ronald Lautner
Niklas Mattsson
Michael Schöll
Kristin Augutis
Kaj Blennow
Bob Olsson
Henrik Zetterberg
Published in International journal of Alzheimer's disease
Volume 2011
Pages 939426
ISSN 2090-0252
Publication year 2011
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 939426
Language en
Links dx.doi.org/10.4061/2011/939426
Subject categories Psychiatry

Abstract

Intensive research over the last decades has provided increasing evidence for neuroinflammation as an integral part in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Inflammatory responses in the central nervous system (CNS) are initiated by activated microglia, representing the first line of the innate immune defence of the brain. Therefore, biochemical markers of microglial activation may help us understand the underlying mechanisms of neuroinflammation in AD as well as the double-sided qualities of microglia, namely, neuroprotection and neurotoxicity. In this paper we summarize candidate biomarkers of microglial activation in AD along with a survey of recent neuroimaging techniques.

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