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Estradiol ameliorates arthritis and protects against systemic bone loss in Staphylococcus aureus infection in mice

Journal article
Authors Inger Gjertsson
Erik Kristiansson
Marie Lagerquist
Catharina Lindholm
Hans Carlsten
Published in Arthritis Research & Therapy
Volume 14
Issue 2
Pages artikel nr R76
ISSN 1478-6362
Publication year 2012
Published at Department of Mathematical Sciences, Mathematical Statistics
Institute of Medicine, Department of Rheumatology and Inflammation Research
Centre for Bone and Arthritis Research
Pages artikel nr R76
Language en
Links dx.doi.org/10.1186/ar3799
https://gup.ub.gu.se/file/184910
Subject categories Clinical Medicine

Abstract

INTRODUCTION: Staphylococcus aureus is a common cause of bacterial arthritis, which is associated with progressive bone loss in affected joints. We have recently shown that S. aureus infection also induces a significant systemic bone loss in mice. This study was performed to assess the effect of estradiol treatment on the clinical course and outcome of S. aureus arthritis and on infection-induced bone loss in experimental S. aureus infection. METHODS: Mice were ovariectomized, treated with estradiol or placebo, and S. aureus infection established by intravenous inoculation of bacteria. RESULTS: Estradiol treatment was found to significantly decrease the frequency and clinical severity of S. aureus arthritis, a finding that was accompanied with significantly higher serum levels of interleukin-10 in estradiol treated mice. Estradiol was also highly protective against S. aureus-induced systemic trabecular and cortical bone loss. Lack of endogenous estrogens and S. aureus infection had additive effects on trabecular bone loss. In fact, S. aureus infected, ovariectomized mice lost as much as 76% of their trabecular bone mass. CONCLUSIONS: Treatment with estradiol ameliorates S. aureus arthritis and is protective against infection-induced systemic bone loss in experimental S. aureus infection.

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