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Accelerated bone formation on photo-induced hydrophilic titanium implants: an experimental study in the dog mandible.

Journal article
Authors Yuko Hirakawa
Ryo Jimbo
Yasuaki Shibata
Ikuya Watanabe
Ann Wennerberg
Takashi Sawase
Published in Clinical oral implants research
Volume 24
Issue A100
Pages 139-144
ISSN 1600-0501
Publication year 2013
Published at
Pages 139-144
Language en
Subject categories Biomaterials

Abstract

OBJECTIVES: The purpose of this study was to investigate the effect of photo-induced hydrophilic titanium dioxide (TiO(2) ) on serum fibronectin (sFN) attachment, and further to evaluate initial osseointegration responses in the dog mandibles. MATERIALS AND METHODS: To apply the anatase TiO(2) film, plasma source ion implantation (PSII) method followed by annealing was employed for the titanium disks and implants, which were then illuminated with UV-A for 24 h for the experimental groups. Non-deposited titanium disks and implants were prepared for the control group. Surface characterization was performed using the interferometer and contact angle analyzer. The attachments of sFN were evaluated using fluorescence emission analysis. Thereafter both groups of implants were placed in the mandible of six beagle dogs. Bone response was investigated with histological and histomorphometrical analyses after periods of 2 and 4 weeks. RESULTS: The experimental groups exhibited strong hydrophilicity under UV-A illumination and showed significant improvement in sFN attachment. And further, the experimental implants enhanced the bone formation with the bone-to-implant contact of 42.7% after 2 weeks of healing (control: 28.4%). CONCLUSIONS: The combined applications of plasma fibronectin and PSII to produce hydrophilic titanium surfaces could accelerate early osseointegration.

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