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Antiretroviral drug treatment of CNS HIV-1 infection.

Journal article
Authors Aylin Yilmaz
Richard W Price
Magnus Gisslén
Published in The Journal of antimicrobial chemotherapy
Volume 67
Issue 2
Pages 299-311
ISSN 1460-2091
Publication year 2012
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 299-311
Language en
Links dx.doi.org/10.1093/jac/dkr492
Keywords cerebrospinal fluid, antiretroviral drugs, pharmacokinetics, pharmacodynamics
Subject categories Microbiology in the medical area

Abstract

The advent of combination antiretroviral treatment has had a profound impact on CNS HIV infection and its clinical complications, but neurological impairment still occurs in patients on systemically effective combination therapy, and in some patients it may be important to consider antiretroviral drug entry and effects within the CNS. There are now data on the CNS exposure for most antiretroviral drugs. This review focuses on the CNS pharmacokinetics and pharmacodynamics of antiretroviral drugs in humans, and also discusses controversies in this field.

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