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Panic disorder is associated with the Val308Iso polymorphism in the hypocretin receptor gene.

Journal article
Authors Kristina Annerbrink
Lars Westberg
Marie Olsson
Sven Andersch
Ingemar Sjödin
Göran Holm
Christer Allgulander
Elias Eriksson
Published in Psychiatric genetics
Volume 21
Issue 2
Pages 85-9
ISSN 1473-5873
Publication year 2011
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 85-9
Language en
Keywords Panic disorder, Val308Iso, hypocretin
Subject categories Pharmacology and Toxicology


Orexin A and B are neuropeptides influencing, for example, arousal and respiration. Although panic disorder is characterized by both enhanced proneness for arousal and by respiratory abnormalities, the possible influence of orexin-related genes on the risk of developing this disorder has not been studied until now.

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