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Increased vascularization of shoulder regions of carotid atherosclerotic plaques from patients with diabetes.

Journal article
Authors Fredrik J. Olson
Sofia Strömberg
Ola Hjelmgren
Josefin Kjelldahl
Björn Fagerberg
Göran Bergström
Published in Journal of vascular surgery
Volume 54
Issue 5
Pages 1324-1331.e5
ISSN 1097-6809
Publication year 2011
Published at Wallenberg Laboratory
Institute of Medicine
Pages 1324-1331.e5
Language en
Links dx.doi.org/10.1016/j.jvs.2011.04.06...
Keywords Aged, Antigens, CD, analysis, Antigens, CD34, analysis, Antigens, Differentiation, Myelomonocytic, analysis, Biological Markers, analysis, Carotid Stenosis, metabolism, pathology, surgery, Chi-Square Distribution, Cross-Sectional Studies, Diabetic Angiopathies, metabolism, pathology, surgery, Endarterectomy, Carotid, Endothelial Cells, chemistry, pathology, Female, Humans, Immunohistochemistry, Logistic Models, Macrophages, chemistry, pathology, Male, Middle Aged, Neovascularization, Pathologic, metabolism, pathology, surgery, Plaque, Atherosclerotic, chemistry, pathology, surgery, Risk Assessment, Risk Factors, Sweden, Vascular Endothelial Growth Factor A, analysis, Vascular Endothelial Growth Factor Receptor-2, analysis
Subject categories Medical and Health Sciences

Abstract

Increased vascularization is considered an important contributing factor for plaque vulnerability. Microvascular proliferative disease in patients with diabetes results in renal damage and visual loss. We assessed the hypothesis that vascularization in carotid atherosclerotic tissue is increased in diabetic patients, especially in the critical shoulder regions of the plaque.

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