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Redox Remodeling by Dendritic Cells Protects Antigen-Specific T Cells against Oxidative Stress

Journal article
Authors Anna Martner
Johan Aurelius
Anna Rydström
Kristoffer Hellstrand
Fredrik Bergh Thorén
Published in Journal of Immunology
Volume 187
Issue 12
Pages 6243-8
ISSN 1550-6606
Publication year 2011
Published at Institute of Biomedicine
Institute of Medicine, Department of Internal Medicine
Institute of Biomedicine, Department of Infectious Medicine
Pages 6243-8
Language en
Subject categories Microbiology in the medical area, Immunobiology

Abstract

Microorganisms and microbial products induce the release of reactive oxygen species (ROS) from monocytes and other myeloid cells, which may trigger dysfunction and apoptosis of adjacent lymphocytes. Therefore, T cell-mediated immunity is likely to comprise mechanisms of T cell protection against ROS-inflicted toxicity. The present study aimed to clarify the dynamics of reduced sulfhydryl groups (thiols) in human T cells after presentation of viral and bacterial Ags by dendritic cells (DCs) or B cells. DCs, but not B cells, efficiently triggered intra- and extracellular thiol expression in T cells with corresponding Ag specificity. After interaction with DCs, the Ag-specific T cells acquired the capacity to neutralize exogenous oxygen radicals and resisted ROS-induced apoptosis. Our results imply that DCs provide Ag-specific T cells with antioxidative thiols during Ag presentation, which suggests a novel aspect of DC/T cell cross-talk of relevance to the maintenance of specific immunity in inflamed or infected tissue.

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