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Does growth hormone treatment influence pubertal development in short children?

Journal article
Authors Anna-Karin Albin
Carina Ankarberg-Lindgren
T. Tuvemo
B. Jonsson
Kerstin Albertsson-Wikland
E. M. Ritzen
Otto Westphal
Ulf Westgren
Published in Hormone Research in Paediatrics
Volume 76
Issue 4
Pages 262-72
ISSN 1663-2826
Publication year 2011
Published at Institute of Clinical Sciences, Department of Pediatrics
Pages 262-72
Language en
Keywords Pubertal onset, Testosterone, Testes, Growth hormone treatment
Subject categories Medical and Health Sciences


AIM: To study the influence of growth hormone (GH) treatment on the initiation and progression of puberty in short children. METHODS: This prospective, randomized, controlled study included 124 short children (33 girls) who received GH treatment (Genotropin(R); Pfizer Inc.) from a mean age of 11 years until near adult height [intent-to-treat (ITT) population]. Children were randomized into three groups: controls (n = 33), GH 33 mug/kg/day (n = 34) or GH 67 mug/kg/day (n = 57). Prepubertal children at study start constituted the per-protocol (PP) population (n = 101). Auxological measurements were made and puberty was staged every 3 months. Serum sex-steroid concentrations were assessed every 6 months. RESULTS: No significant differences were found between the groups, of both PP and ITT populations, in time elapsed from start of treatment until either onset of puberty, age at start of puberty or age at final pubertal maturation in either sex. In the ITT population, pubertal duration was significantly longer in GH-treated girls, and maximum mean testicular volume was significantly greater in GH-treated boys than controls, but there were no differences in testosterone levels between the groups. CONCLUSION: GH treatment did not influence age at onset of puberty and did not accelerate pubertal development. In boys, GH treatment appeared to increase testicular volume.

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