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In vivo stability of hydroxyapatite nanoparticles coated on titanium implant surfaces.

Journal article
Authors Ann Wennerberg
Ryo Jimbo
Stefan Allard
Gunnar Skarnemark
Martin Andersson
Published in The International journal of oral & maxillofacial implants
Volume 26
Issue 6
Pages 1161-6
ISSN 1942-4434
Publication year 2011
Published at Institute of Clinical Sciences, Department of Biomaterials
Pages 1161-6
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Biomaterials

Abstract

Purpose: Nanotechnology has been employed in attempts to enhance bone incorporation of dental implants. Often, nanoparticles are applied to the implant surface as particle coatings. However, the same properties that may increase the functionality may also lead to undiscovered negative effects, such as instability of the nanocoating. The aim of this study was to investigate the stability÷instability of the nanoparticles using a radiolabeling technique. Materials and Methods: Twenty threaded and turned titanium microimplants were inserted in 10 rats. All 20 implants were coated with nanometer-sized hydroxyapatite (HA) particles. In order to trace the HA nanoparticles, the particles for 16 implants were labeled with calcium 45 (45Ca). After 1, 2, 4, and 8 weeks, the implants and surrounding bone were retrieved and analyzed using autoradiography with respect to particle migration from the implant surface. Samples from the brain, liver, thymus, kidney, and blood, as well as wooden shavings from the rats' cages, were also retrieved and analyzed using liquid scintillation counting. Results: The radioactivity representing the localization of 45Ca decreased over time from the vicinity of the implant. The amounts of 45Ca found in the blood and in the rats' excretions decreased with time and corresponded well to each other. After 8 weeks, the only trace of 45Ca was found in the liver. Conclusion: The results indicated that released particles leave the body through the natural cleaning system, and the probability that the nanocoating will assemble in vital organs and thus become a potential biologic risk factor is unlikely. Int J Oral Maxillofac Implants 2011;26:1161-1166.

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