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3D modeling of effects of increased oxygenation and activity concentration in tumors treated with radionuclides and antiangiogenic drugs.

Journal article
Authors Jakob Heydorn Lagerlöf
Jon Kindblom
Peter Bernhardt
Published in Medical physics
Volume 38
Issue 8
Pages 4888-93
ISSN 0094-2405
Publication year 2011
Published at Institute of Clinical Sciences, Department of Radiation Physics
Pages 4888-93
Language en
Links dx.doi.org/10.1118/1.3615164
Keywords Angiogenesis Inhibitors, therapeutic use, Glioblastoma, blood supply, drug therapy, metabolism, radiotherapy, Humans, Imaging, Three-Dimensional, Models, Biological, Models, Statistical, Neoplasms, blood supply, drug therapy, metabolism, radiotherapy, Oxygen Consumption, drug effects, radiation effects, Radioisotopes, therapeutic use, Vascular Endothelial Growth Factor A, antagonists & inhibitors
Subject categories Cancer and Oncology, Radiological physics, Radiation biology

Abstract

Formation of new blood vessels (angiogenesis) in response to hypoxia is a fundamental event in the process of tumor growth and metastatic dissemination. However, abnormalities in tumor neovasculature often induce increased interstitial pressure (IP) and further reduce oxygenation (pO2) of tumor cells. In radiotherapy, well-oxygenated tumors favor treatment. Antiangiogenic drugs may lower IP in the tumor, improving perfusion, pO2 and drug uptake, by reducing the number of malfunctioning vessels in the tissue. This study aims to create a model for quantifying the effects of altered pO2-distribution due to antiangiogenic treatment in combination with radionuclide therapy.

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