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The formation of lipid droplets: possible role in the development of insulin resistance/type 2 diabetes.

Journal article
Authors Sven-Olof Olofsson
Linda Andersson
Liliana Håversen
Kristina Olsson
Susanna Myhre
Mikael Rutberg
Reza Mobini
Lu Li
Emma Lu
Jan Borén
Pontus Boström
Published in Prostaglandins, leukotrienes, and essential fatty acids
Volume 85
Issue 5
Pages 215-8
ISSN 1532-2823
Publication year 2011
Published at Wallenberg Laboratory
Institute of Biomedicine, Department of Microbiology and Immunology
Institute of Clinical Sciences, Department of Pediatrics
Institute of Medicine, Department of Molecular and Clinical Medicine
Institute of Clinical Sciences
Pages 215-8
Language en
Links dx.doi.org/10.1016/j.plefa.2011.04....
Subject categories Medical and Health Sciences

Abstract

Neutral lipids are stored in so-called lipid droplets, which are formed as small primordial droplets at microsomal membranes and increase in size by a fusion process. The fusion is catalyzed by the SNARE proteins SNAP23, syntaxin-5 and VAMP4. SNAP23 is involved in the insulin dependent translocation of GLUT4 to the plasma membrane, and has an important role in the development of insulin resistance. Thus fatty acids relocalize SNAP23 from the plasma membrane (and the translocation of GLUT 4) to the interior of the cell giving rise to insulin resistance. Moreover this relocalization is seen in skeletal muscles biopsies from patients with type 2 diabetes compared to matched control. Thus a missorting of SNAP23 is essential for the development of insulin resistance.

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