To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Metabolic benefits of gro… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Metabolic benefits of growth hormone therapy in idiopathic short stature.

Journal article
Authors Jovanna Dahlgren
Published in Hormone research in pædiatrics
Volume 76 Suppl 3
Pages 56-8
ISSN 1663-2826
Publication year 2011
Published at Institute of Clinical Sciences, Department of Pediatrics
Pages 56-8
Language en
Subject categories Immunobiology


The US Food and Drug Administration approved use of recombinant human growth hormone (GH) for the treatment of idiopathic short stature (ISS) in children; however, few studies have evaluated metabolic outcomes. This article addresses whether children with ISS treated with GH experience the same metabolic benefits as children with GH deficiency (GHD) treated with GH. A systematic review of all published studies of GH treatment in children with ISS that included data on metabolic outcomes identified five studies. No meta-analysis has been performed.Studies show a metabolic response to GH treatment in children with ISS similar to that observed in children with GHD; effects include a transient decrease in insulin sensitivity and a dose-dependent increase in insulin-like growth factor I. However, no increase in the risk of diabetes was found. Children with ISS seem to benefit from GH treatment in terms of height gain without any severe negative metabolic outcomes.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?