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International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments

Journal article
Authors I Ponjaert-Kristoffersen
M Bonduelle
J Barnes
J Nekkebroeck
A Loft
Ulla-Britt Wennerholm
BC Tarlatzis
C Peters
Bibbi Hagberg
A Berner
G Sutcliffe A
Published in Pediatrics
Volume 115
Issue 3
Pages e283-289
ISSN 1098-4275
Publication year 2005
Published at Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology
Department of Psychology
Pages e283-289
Language en
Keywords Case-Control Studies, Child Development, Child, Preschool, Europe, Female, Fertilization, Fertilization in Vitro, Humans, Intelligence, Male, Motor Skills, Psychological Tests, Reference Values, Selection Bias, Sperm Injections, Intracytoplasmic
Subject categories Psychiatry


Objective. To date, very few studies have been conducted on the neurodevelopmental well-being of children conceived through intracytoplasmic sperm injection (ICSI). The limitations of these studies often include a lack of comparison with a demographically matched, naturally conceived (NC) group and the investigation of only very young children, with relatively small samples sizes. One study showed that there were no differences in IQ scores among ICSI-conceived, in vitro fertilization (IVF)-conceived, and NC children at 5 years of age. Unfortunately, psychomotor development was not assessed in that study. Because findings regarding these children's cognitive and motor development are inconclusive, the aim of this study was to shed more light on the cognitive and motor development of 5-year-old ICSI-conceived children.

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