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The effect of hydroxyapatite nanocrystals on early bone formation surrounding dental implants.

Journal article
Authors Lory Melin Svanborg
Maria Hoffman
Martin Andersson
F Currie
P Kjellin
Ann Wennerberg
Published in International journal of oral and maxillofacial surgery
Volume 40
Issue 3
Pages 308-15
ISSN 1399-0020
Publication year 2011
Published at Institute of Clinical Sciences, Department of Biomaterials
Pages 308-15
Language en
Keywords Acid Etching, Dental, Animals, Coated Materials, Biocompatible, chemistry, Dental Etching, Dental Implants, Dental Materials, chemistry, Dental Prosthesis Design, Durapatite, chemistry, Materials Testing, Microscopy, Electron, Scanning, Models, Animal, Nanoparticles, chemistry, Osseointegration, physiology, Osteogenesis, physiology, Photoelectron Spectroscopy, Rabbits, Surface Properties, Tibia, pathology, surgery, Time Factors, Titanium, chemistry, Torque, nanostructures, surface topography, hydroxyapatite coat, dental, implants, in vivo study, acid-etched surface, titanium implants, calcium-phosphate, in-vitro, osteoblast adhesion, enhanced functions, removal torque, oral implants, coatings, vivo
Subject categories Dentistry, Biomaterials, Surgery, Surgical research


The knowledge of how nanostructures might affect early bone healing and osseointegration is limited. The aim of this study was to investigate if nanometer thick coatings of hydroxyapatite nanocrystals applied on a moderately rough surface might enhance early bone healing on screw-shaped dental implants and to evaluate if the thickness of the coat influences healing. Sandblasted and acid etched titanium implants coated with two different thicknesses of hydroxyapatite (test implants) and sandblasted and acid etched titanium implants (control implants), were inserted in rabbit tibia. After a healing time of 2, 4 and 9 weeks, a removal torque analysis and a histological evaluation were performed. The results from the removal torque analysis showed a tendency for higher values for the double coated hydroxyapatite after 4 weeks and for both the coated surfaces after 9 weeks of healing. The histological evaluations indicated slightly more new bone formation with the coated implants compared with the control; the differences did not reach statistical significance. The present study could not support the importance of nanometer thick coatings of hydroxyapatite nanocrystals in early bone healing, at least not when applied on a blasted and etched surface and placed in a cortical bone.

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