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Depression in Myotonic Dystrophy type 1: clinical and neuronal correlates.

Journal article
Authors Stefan Winblad
Christer Jensen
Jan-Eric Månsson
Lena Samuelsson
Christopher Lindberg
Published in Behavioral and brain functions : BBF
Volume 6
Pages art. 25
ISSN 1744-9081
Publication year 2010
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Department of Psychology
Institute of Clinical Sciences
Pages art. 25
Language en
Links dx.doi.org/10.1186/1744-9081-6-25
Keywords Adolescent, Adult, Brain, pathology, Depressive Disorder, epidemiology, pathology, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Muscular Atrophy, Spinal, epidemiology, pathology, Muscular Dystrophies, Limb-Girdle, epidemiology, pathology, Muscular Dystrophy, Facioscapulohumeral, epidemiology, pathology, Myotonic Dystrophy, epidemiology, pathology, Nerve Fibers, Myelinated, pathology, Prevalence, Psychiatric Status Rating Scales, Risk Factors, Young Adult
Subject categories Medical and Health Sciences

Abstract

Background This study was designed to investigate the prevalence and correlates of depression in Myotonic dystrophy type 1 (DM1). Methods Thirty-one patients with DM1 and 47 subjects in a clinical contrast group, consisting of other neuromuscular disorders, including Spinal muscular atrophy, Limb girdle muscle atrophy and Facioscapulohumeral dystrophy, completed Beck Depression Inventory (BDI). We aimed to establish whether different factors associated with DM1 correlated with ratings in the BDI. Results Signs of a clinical depression were prevalent in 32% of the patients with DM1, which was comparable with ratings in the clinical contrast group. The depressive condition was mild to moderate in both groups. In DM1, a longer duration of clinical symptoms was associated with lower scores on the BDI and higher educational levels were correlated with higher scores on depression. We also found a negative association with brain white matter lesions. Conclusions Findings indicate significantly more DM1 patients than normative collectives showing signs of a clinical depression. The depressive condition is however mild to moderate and data indicate that the need for intervention is at hand preferentially early during the disease process.

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