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A subset of human pancreatic beta cells express functional CD14 receptors: a signaling pathway for beta cell-related glycolipids, sulfatide and β-galactosylceramide.

Journal article
Authors Thomas Osterbye
David P Funda
Petra Fundová
Jan-Eric Månsson
Helena Tlaskalová-Hogenová
Karsten Buschard
Published in Diabetes/metabolism research and reviews
Volume 26
Issue 8
Pages 656-67
ISSN 1520-7560
Publication year 2010
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 656-67
Language en
Links dx.doi.org/10.1002/dmrr.1134
Keywords Adult, Animals, Antigens, CD14, biosynthesis, metabolism, Cells, Cultured, Female, Galactosylceramides, metabolism, Glycolipids, metabolism, Humans, Insulin-Secreting Cells, metabolism, Interleukin-8, Lipopolysaccharides, pharmacology, Male, Rats, Signal Transduction, Sulfoglycosphingolipids, metabolism, Tumor Necrosis Factor-alpha, biosynthesis
Subject categories Psychiatry

Abstract

T1DM is a T-cell-mediated autoimmune disease targeting insulin-producing beta-cells. Multiple factors may contribute to the development of T1DM. Among these, the metabolic state of beta-cells and pro-inflammatory cytokines, produced by infiltrating immune cells, have been implicated in the precipitation of T1DM.

Page Manager: Webmaster|Last update: 9/11/2012
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