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High white matter lesion load is associated with hippocampal atrophy in mild cognitive impairment.

Journal article
Authors Carl Eckerström
Erik Olsson
Niklas Klasson
Maria Bjerke
Mattias Göthlin
Michael Jonsson
Sindre Rolstad
Helge Malmgren
Anders Wallin
Åke Edman
Published in Dementia and geriatric cognitive disorders
Volume 31
Issue 2
Pages 132-8
ISSN 1421-9824
Publication year 2011
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Department of Philosophy, Linguistics and Theory of Science
Pages 132-8
Language en
Keywords Aged, Alzheimer Disease, pathology, psychology, Apolipoproteins E, genetics, Atrophy, Brain, pathology, Cognition Disorders, pathology, psychology, Dementia, Vascular, pathology, psychology, Educational Status, Female, Hippocampus, pathology, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests
Subject categories Psychiatry, Philosophy


Mild cognitive impairment (MCI) is a heterogeneous condition suggested as a prodromal state of Alzheimer's disease (AD) and subcortical vascular dementia (SVD). Recent findings suggest that white matter lesions (WML) may be associated with hippocampal atrophy. The objective of the study was to examine hippocampal and WML volumes in MCI patients and to examine if WML were linked to hippocampal atrophy.

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