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Genetic variation in complement component C3 shows association with ischaemic stroke.

Journal article
Authors Sandra Olsson
Anna Stokowska
Lukas Holmegaard
Katarina Jood
Christian Blomstrand
Marcela Pekna
Christina Jern
Published in European journal of neurology : the official journal of the European Federation of Neurological Societies
Volume 42
Pages 214-16
ISSN 1468-1331
Publication year 2011
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 214-16
Language en
Links dx.doi.org/10.1111/j.1468-1331.2011...
https://gup.ub.gu.se/file/86207
Subject categories Medical and Health Sciences

Abstract

Background and purpose:  The aim of this study was to investigate whether genetic variation at the third complement component (C3) locus is associated with ischaemic stroke (IS). Methods:  The Sahlgrenska Academy Study on Ischaemic Stroke comprises 844 patients with IS, and 668 healthy controls. Sixteen SNPs were analyzed. Results:  Two SNPs, rs2277984 and rs3745565, showed a significant association with overall IS. The SNP rs2277984 also showed association with the IS subtype cryptogenic stroke. These associations were independent of hypertension, diabetes, and smoking. The independent association between rs3745565 and overall IS withstands correction for multiple testing. Conclusion:  In this sample of patients with IS, genetic variation in C3 is associated with IS.

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