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The effect of live, attenuated measles vaccine and measles infection on measles antibody levels in serum and CSF of patients with multiple sclerosis or clinically isolated syndrome.

Journal article
Authors Cecilia Ahlgren
Anders Odén
Sara Haghighi
Oluf Andersen
Tomas Bergström
Jan Lycke
Published in Journal of neuroimmunology
Volume 235
Issue 1-2
Pages 98-103
ISSN 1872-8421
Publication year 2011
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Department of Mathematical Sciences, Mathematical Statistics
Institute of Biomedicine, Department of Infectious Medicine
Pages 98-103
Language en
Keywords Adolescent, Adult, Antibodies, Viral, blood, cerebrospinal fluid, Child, Preschool, Demyelinating Diseases, blood, cerebrospinal fluid, immunology, Female, Humans, Male, Measles, blood, cerebrospinal fluid, immunology, Measles Vaccine, immunology, therapeutic use, Middle Aged, Multiple Sclerosis, blood, cerebrospinal fluid, immunology, Vaccines, Attenuated, immunology, therapeutic use, Young Adult
Subject categories Medical and Health Sciences


High occurrence of measles, rubella and varicella zoster antibodies has been used as a biomarker for MS (the MRZ test). We analyzed measles antibody titres with respect to measles infection/measles vaccination status in 166 patients with MS or clinically isolated syndrome. Fifty blood donors served as controls. Measles vaccination yielded CSF measles antibodies in fewer patients (62%) than measles infection did (87%, p=0.001) and yielded lower measles titres in both serum and CSF (p<0.001). Controls had lower CSF measles titres than patients with measles vaccination alone (p<0.001). Childhood vaccinations probably reduce the sensitivity of the MRZ diagnostic test for MS.

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