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Screening for new biomarkers for subcortical vascular dementia and Alzheimer's disease

Journal article
Authors Annika Öhrfelt Olsson
Ulf Andreasson
Adam Simon
Henrik Zetterberg
Åke Edman
William Potter
Daniel Holder
Viswanath Devanarayan
Jeffrey Seeburger
David A Smith
Kaj Blennow
Anders Wallin
Published in Dementia and Geriatric Cognitive Disorders Extra
Volume 1
Issue 1
Pages 31-42
ISSN 1664-5464
Publication year 2011
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 31-42
Language en
Links dx.doi.org/10.1159/000323417
Keywords Alzheimer’s disease, Biomarkers, Cerebrospinal fluid, Mild cognitive impairment, Vascular dementia
Subject categories Psychiatry

Abstract

Background: Novel biomarkers are important for identifying as well as differentiating subcortical vascular dementia (SVD) and Alzheimer’s disease (AD) at an early stage in the disease process. Methods: In two independent cohorts, a multiplex immunoassay was utilized to analyze 90 proteins in cerebrospinal fluid (CSF) samples from dementia patients and patients at risk of developing dementia (mild cognitive impairment). Results: The levels of several CSF proteins were increased in SVD and its incipient state, and in moderate-to-severe AD compared with the control group. In contrast, some CSF proteins were altered in AD, but not in SVD. The levels of heart-type fatty acid binding protein (H-FABP) were consistently increased in all groups with dementia but only in some of their incipient states. Conclusions: In summary, these results support the notion that SVD and AD are driven by different pathophysiological mechanisms reflected in the CSF protein profile and that H-FABP in CSF is a general marker of neurodegeneration

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