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Biomechanical, histological and ultrastructural analyses of laser micro- and nano-structured titanium implant after 6 months in rabbit.

Journal article
Authors Anders Palmquist
Lena Emanuelsson
Rickard Brånemark
Peter Thomsen
Published in Journal of biomedical materials research. Part B, Applied biomaterials
Volume 97
Issue 2
Pages 289-98
ISSN 1552-4981
Publication year 2011
Published at Institute of Clinical Sciences, Department of Biomaterials
Institute of Clinical Sciences, Department of Orthopaedics
Pages 289-98
Language en
Keywords Animals, Coated Materials, Biocompatible, chemistry, metabolism, Female, Femur, anatomy & histology, metabolism, Implants, Experimental, Lasers, Materials Testing, Microscopy, Electron, Osseointegration, Rabbits, Stress, Mechanical, Surface Properties, Tibia, anatomy & histology, metabolism, Titanium, chemistry, metabolism
Subject categories Biomaterials Science


Short-term, experimental studies of partly laser-modified implants with nano-scale surface topographical features have recently shown a considerable increase in the biomechanical anchorage to bone. The aim of this study is to evaluate the biomechanical and bone-bonding ability of partly laser-modified implants compared with machined implants after a healing period of 6 months in a rabbit model. The results showed a 170% increase in removal torque. Histology and scanning electron microscopy demonstrated osseointegration for both implant types, but also revealed a different fracture pattern at the interface and in the bone. Transmission electron microscopy and chemical analysis showed coalescence between mineralized tissue and the nano-structured surface of the laser modified implant. Taken together, the results indicate that nano-structured surfaces promote in vivo long-term bone bonding and interface strength.

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