To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Acute Inflammatory Respon… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Acute Inflammatory Response to Laser-Induced Micro- and Nano-Sized Titanium Surface Features.

Journal article
Authors Anders Palmquist
Anna Johansson
Felicia Suska
Rickard Brånemark
Peter Thomsen
Published in Clinical implant dentistry and related research
Volume 15
Issue 1
Pages 96–104
ISSN 1708-8208
Publication year 2013
Published at Institute of Clinical Sciences, Department of Biomaterials
Pages 96–104
Language en
Links dx.doi.org/10.1111/j.1708-8208.2011...
Keywords cytokines; inflammation; laser modification; nanotopography; titanium
Subject categories Clinical Medicine, Biomaterials Science

Abstract

Background: The inflammatory process induced by implant surfaces is an important component of the tissue response, where limited knowledge is available regarding the role of surface topography. With laser ablation, a combined micro- and nanoscale surfacemodification could be created, which have been shown to enhance bone growth and biomechanical stability in vivo. Purpose: The aim of this article was to evaluate the early in vivo inflammatory response to laser-modified titanium disks, with machined titanium disks and sham operation sites serving as controls. Materials and Methods: Circular disks were installed in a subcutaneous rat model for 24 and 72 hours, where the cell number, cell types, and cytokine levels were evaluated. Results: The results revealed that significantly fewer inflammatory cells (mononuclear and polymorphonuclear) were attracted to the sites with the laser-modified implants compared with the machined titanium implants. Similar concentrations of pro-inflammatory cytokines (TNF-a and MCP-1), together with slightly higher cell viability, were observed around the laser-modified surface compared with the machined surface. Conclusions: The results in the present study suggest that the combination of surface micro and nano features of the laser-treated surface contributes to the downregulation of early inflammatory events.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?