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Autistic disorders in children with CHARGE association

Journal article
Authors Elisabeth Fernell
Vivi-Ann Olsson
Carina Karlgren-Leitner
Berit Norlin
Bibbi Hagberg
Christopher Gillberg
Published in Developmental Medicine and Child Neurology
Volume 41
Issue 4
Pages 270-272
ISSN 0012-1622
Publication year 1999
Published at Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry
Pages 270-272
Language en
Links onlinelibrary.wiley.com/doi/10.1111...
Keywords Abnormalities, Multiple, Autistic Disorder, Complications, Female, Humans, Infant, Infant, Newborn
Subject categories Child and adolescent psychiatry

Abstract

Three children with CHARGE association (coloboma, heart defect, atresia of the choanae, retarded growth and development, genital hypoplasia, ear anomalies and hearing defects) as well as concomitant autistic disorder are reported. Two of the children also had mental retardation. Several types of cerebral maldevelopment/dysfunction have been reported in CHARGE association. With regard to aetiology, involvement of the neural crest has been suggested. Autism in CHARGE association may represent a neuro-endocrine dysfunction. Children with a CHARGE association have many medical problems and therefore autistic behaviour can easily be overlooked. A multidisciplinary approach with respect to assessment, treatment, and habilitation is of vital importance.

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