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Prolonged moderate pressure recruitment manoeuvre results in lower optimal positive end-expiratory pressure and plateau pressure.

Journal article
Authors Karin Lowhagen
Sophie Lindgren
Helena Odenstedt
Ola Stenqvist
Stefan Lundin
Published in Acta anaesthesiologica Scandinavica
Volume 55
Issue 2
Pages 175-84
ISSN 1399-6576
Publication year 2011
Published at Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
Pages 175-84
Language en
Keywords Acute Lung Injury, physiopathology, therapy, Aged, Anesthetics, Intravenous, pharmacology, Cardiac Output, physiology, Cross-Over Studies, Electric Impedance, Female, Fentanyl, pharmacology, Humans, Hypnotics and Sedatives, pharmacology, Lung Compliance, physiology, Lung Volume Measurements, Male, Middle Aged, Positive-Pressure Respiration, methods, Propofol, pharmacology, Prospective Studies, Pulmonary Gas Exchange, physiology, Respiration, Artificial, Respiratory Distress Syndrome, Adult, physiopathology, therapy, Respiratory Mechanics, physiology, Vital Capacity
Subject categories Anesthesiology and Intensive Care


In acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), recruitment manoeuvres (RMs) are used frequently. In pigs with induced ALI, superior effects have been found using a slow moderate-pressure recruitment manoeuvre (SLRM) compared with a vital capacity recruitment manoeuvre (VICM). We hypothesized that the positive recruitment effects of SLRM could also be achieved in ALI/ARDS patients. Our primary research question was whether the same compliance could be obtained using lower RM pressure and subsequent positive end-expiratory pressure (PEEP). Secondly, optimal PEEP levels following the RMs were compared, and the use of volume-dependent compliance (VDC) to identify successful lung recruitment and optimal PEEP was evaluated.

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