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Treatment-related deaths in second complete remission in childhood acute myeloid leukaemia.

Journal article
Authors Lene Molgaard-Hansen
Merja Möttönen
Heidi Glosli
Guðmundur K Jónmundsson
Jonas Abrahamsson
Henrik Hasle
Lotta Mellander
Published in British journal of haematology
Volume 152
Issue 5
Pages 623-30
ISSN 1365-2141
Publication year 2011
Published at Institute of Clinical Sciences, Department of Pediatrics
Pages 623-30
Language en
Links dx.doi.org/10.1111/j.1365-2141.2010...
Keywords Adolescent, Antineoplastic Combined Chemotherapy Protocols, adverse effects, therapeutic use, Child, Child, Preschool, Disease Progression, Epidemiologic Methods, Female, Graft vs Host Disease, mortality, Hematopoietic Stem Cell Transplantation, adverse effects, Humans, Infant, Leukemia, Myeloid, Acute, drug therapy, mortality, Male, Opportunistic Infections, mortality, Recurrence, Remission Induction, Scandinavia, epidemiology
Subject categories Cancer and Oncology, Children

Abstract

The frequency and causes of treatment-related deaths (TRD) in second complete remission (CR2) in acute myeloid leukaemia (AML) were investigated in a historical, prospective cohort study of 429 children included in the Nordic Society of Paediatric Haematology and Oncology (NOPHO)-AML-88 and -93 trials. Relapse occurred in 158 children (39%). Seventeen (18%) of the 96 patients entering CR2 suffered TRD. The main causes were infection (59%) and complications from graft-versus-host disease (22%). Fourteen (82%) of 17 TRDs occurred in children undergoing haematopoietic stem cell transplantations (HSCT). Optimal supportive care after HSCT is essential, and studies on risk factors for TRD are needed.

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