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Association between genetic variation on chromosome 9p21 and aneurysmal subarachnoid haemorrhage.

Journal article
Authors Sandra Olsson
Ludvig Z Csajbok
Katarina Jood
Karin Nylén
Bengt Nellgård
Christina Jern
Published in Journal of Neurology, Neurosurgery and Psychiatry
Volume 82
Issue 4
Pages 384-8
ISSN 1468-330X
Publication year 2011
Published at Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 384-8
Language en
Links dx.doi.org/10.1136/jnnp.2009.187427
https://gup.ub.gu.se/file/86206
Keywords Adult, Aged, Aged, 80 and over, Alleles, Aneurysm, Ruptured, complications, genetics, Chromosomes, Human, Pair 9, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Hypertension, complications, genetics, Intracranial Aneurysm, complications, genetics, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Smoking, genetics, Subarachnoid Hemorrhage, complications, genetics
Subject categories Neurosurgery

Abstract

Genetic factors play a role in susceptibility to subarachnoid haemorrhage, but little is known about which genes are involved. Recently, genome wide association studies have identified the 9p21 region as a risk locus for intracranial aneurysms (IA). The aim of the present study was to examine the possible association between 9p21 and ruptured IA--that is, aneurysmal subarachnoid haemorrhage (aSAH)--in a Swedish population. There is one study showing an association between 9p21 and arterial stiffness, and arterial stiffness plays a role in the development of hypertension. Therefore, a second aim was to investigate whether a putative association is independent of hypertension.

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