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Genotype X/C recombinant (putative genotype I) of hepatitis B virus is rare in Hanoi, Vietnam—genotypes B4 and C1 predominate

Journal article
Authors Phung Thi Bich Thuy
Erik Alestig
Charles Hannoun
Nguyen Thanh Liem
Magnus Lindh
Published in Journal of medical virology
Volume 82
Issue 8
Pages 1327-1333
ISSN 0146-6615
Publication year 2010
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 1327-1333
Language en
Links dx.doi.org/10.1002/jmv.21775
Keywords complete genome sequence, virological characteristics, clinical characteristics, interferon therapy, precore region, liver-disease, core promoter, subgenotypes, infection, strains
Subject categories Medical and Health Sciences

Abstract

There are eight known genotypes of hepatitis B virus, A–H, and several subgenotypes, with rather well-defined geographic distributions. HBV genotypes were evaluated in 153 serum samples from Hanoi, Vietnam. Of the 87 samples that could be genotyped, genotype B was found in 67 (77%) and genotype C in 19 (22%). All genotype C strains were of subgenotype C1, and the majority of genotype B strains were B4, while a few were B2. The genotype X/C recombinant strain, identified previously in Swedish patients of indigenous Vietnamese origin, was found in one sample. This variant, proposed to be classified as genotype I, has been found recently also by others in Vietnam and Laos. The current study indicates that the genotype X/C recombinant may represent approximately 1% of the HBV strains circulating in Vietnam.

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