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Early-age changes in oxidative stress in brown trout, Salmo trutta

Journal article
Authors Bethanie Carney Almroth
Angelica Johansson
Lars Förlin
Joachim Sturve
Published in COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
Volume 155
Issue 4
Pages 442-448
ISSN 1096-4959
Publication year 2010
Published at Department of Zoology
Pages 442-448
Language en
Links dx.doi.org/10.1016/j.cbpb.2010.01.0...
Keywords microtiter plate assay, free-radical theory, protein carbonyls, rainbow-trout, life-span, glutathione disulfide, antioxidant defenses, compensatory growth, gradual senescence, fish
Subject categories Natural Sciences

Abstract

Fish are often used as models for studies investigating the ability of xenobiotics to induce oxidative stress, though age or developmental stage of the individuals studied has been given little attention. Oxidative stress in other organisms is associated with aging as well as with periods of rapid growth, which occurs in young brown trout. We measured protein carbonyls, 20S proteosome activity and glutathione (GSH) levels in farmed Salmo trutta in four different age groups from 5 months to 3 years. We found an increase in protein carbonyls and a decrease in 20S proteosome activity in both brain and liver tissues of the fish with increasing size and age. Total GSH levels in liver tissue declined as fish aged and the GSSG:GSH ratio increased. Five month and 1 year old trout were treated with paraquat (PQ) to induce oxidative stress. Five month old fish showed no changes in the measured parameters while 1 year old fish had both an increase in protein carbonylation in liver tissue and a decrease in 20S proteosome activity in brain tissue. These results indicate that oxidative stress biomarkers are affected by age or rapid growth in brown trout, and that individuals of different ages respond differently to oxidative stress induced by PQ.

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