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The effect of calcium ion concentration on the bone response to oxidized titanium implants

Journal article
Authors Byung-Soo Kang
Young-Taeg Sul
Carina B. Johansson
Hyun-Ju Lee
Se-Jung Oh
Tomas Albrektsson
Published in Clinical Oral Implants Research
Volume 23
Issue 6
Pages 690-697
ISSN 0905-7161
Publication year 2012
Published at Institute of Clinical Sciences, Department of Biomaterials
Pages 690-697
Language en
Keywords bone response;calcium concentration;micro-arc oxidation;shear strength;surface chemistry;titanium implant
Subject categories Surface engineering, Biomaterials


Aim: To investigate the effect of calcium concentration on the bone tissue response to Ca-incorporated titanium implants Materials and methods: Two titanium surfaces containing 4.2% and 6.6% calcium were prepared using the micro-arc oxidation process. The implants were inserted in the tibia of nine New Zealand White rabbits. After 6 weeks of healing, the bone response to the implants was quantitatively compared by biomechanical and histomorphometrical measurements. Results: Ca 4.2% and Ca 6.6% containing implants revealed no distinctive differences in their qualitative surface chemistry; chemical bonding state of Ca in titanium oxide was mainly calcium titanates. No significant differences were observed between two implants in peak removal torque and shear strength comparisons (P>0.05). Histomorphometrical analyses presented no significant differences in bone-metal contact, bone area and newly formed bone measurements between two implants (P>0.05). Conclusions: From biomechanical and histomorphometrical measurements, the two calcium concentrations in this study did not differ significantly with respect to their influence on the bone tissue response. This similar bone response in rabbit tibiae may be explained by the similarity of the qualitative Ca chemistry in titanium surfaces.

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