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CD1d expression in paneth cells and rat exocrine pancreas revealed by novel monoclonal antibodies which differentially affect NKT cell activation.

Journal article
Authors Elisa Monzon-Casanova
Birte Steiniger
Stefanie Schweigle
Holger Clemen
Daniela Zdzieblo
Lisa Starick
Ingrid Müller
Chyung-Ru Wang
Sara Rhost
Susanna Cardell
Elwira Pyz
Thomas Herrmann
Published in PloS one
Volume 5
Issue 9
ISSN 1932-6203
Publication year 2010
Published at Institute of Biomedicine
Institute of Biomedicine, Department of Microbiology and Immunology
Language en
Links dx.doi.org/10.1371/journal.pone.001...
Subject categories Microbiology in the medical area

Abstract

CD1d is a nonpolymorphic MHC class I-like molecule which presents nonpeptide ligands, e.g. glycolipids, to NKT cells. These cells are known to have multiple effects on innate and adaptive immune responses and on the development of pathological conditions. In order to analyze CD1d expression and function in the rat, the first rat CD1d-specific monoclonal antibodies (mAbs) were generated.

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