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HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment.

Journal article
Authors Arvid Edén
Dietmar Fuchs
Lars Hagberg
Staffan Nilsson
Serena Spudich
Bo Svennerholm
Richard W Price
Magnus Gisslén
Published in The Journal of infectious diseases
Volume 202
Issue 12
Pages 1819-25
ISSN 1537-6613
Publication year 2010
Published at Department of Mathematical Sciences, Mathematical Statistics
Institute of Biomedicine, Department of Infectious Medicine
Pages 1819-25
Language en
Keywords Anti-HIV Agents, Blood-Brain Barrier, Cerebrospinal Fluid, virology, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, HIV Infections, drug therapy, virology, HIV-1, isolation & purification, Humans, Male, Middle Aged, Neopterin, analysis, Plasma, virology, RNA, Viral, isolation & purification, Reverse Transcriptase Polymerase Chain Reaction, Treatment Outcome, Viral Load
Subject categories Infectious Medicine


Occasional cases of viral escape in cerebrospinal fluid (CSF) despite suppression of plasma human immunodeficiency virus type 1 (HIV-1) RNA have been reported. We investigated CSF viral escape in subjects treated with commonly used antiretroviral therapy regimens in relation to intrathecal immune activation and central nervous system penetration effectiveness (CPE) rank.

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