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GH dosing guided by individual responsiveness decreases variability in growth response and insulin in GHD and ISS children

Authors Berit Kriström
Ralph Decker
Jovanna Dahlgren
Jan Gustafsson
Ze'ev Hochberg
Kerstin Albertsson-Wikland
Published in New Inroads to Child Health (NICHe)
Publication year 2010
Published at Institute of Clinical Sciences, Department of Pediatrics
Language en
Keywords growth hormone, prediction model, individual dosing
Subject categories Clinical pharmacology, Clinical physiology


GH responsiveness on growth can be estimated before treatment by use of prediction models in GHD and ISS children, and may be used for individualizing the GH dose to reach a set goal for catch-up growth, i.e. Midparental Height (MPH) SDS. Conclusions: The prospective randomized study shows that by using the GH responsiveness estimated by our prediction model for individualizing the GH dose during 2 years of catch-up growth, too low and too high growth response can be avoided, and the variance in fasting insulin and HOMA was reduced.

Page Manager: Webmaster|Last update: 9/11/2012

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