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Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation.

Journal article
Authors Hui Wang
Reza Mobini
Yu Fang
Fredrik Barrenäs
H Zhang
Z Xiang
Mikael Benson
Published in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Volume 40
Issue 8
Pages 1194-202
ISSN 1365-2222
Publication year 2010
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Institute of Clinical Sciences, Department of Pediatrics
Pages 1194-202
Language en
Keywords allergic rhinitis; glucocorticoids; gene expression microarray analysis; proteomics.
Subject categories Allergology


Previously, expression profiling has been used to analyse allergen-challenged T-helper type 2 cells, nasal biopsies and nasal fluid cells from patients with seasonal allergic rhinitis (SAR). Allergen-challenged peripheral blood mononuclear cells (PBMCs) provide a human in vitro model of how antigen-presenting cells, CD4+ T cells and effector cells such as basophils interact in allergic inflammation.

Page Manager: Webmaster|Last update: 9/11/2012

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