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Nonresponder patients with hepatitis C virus genotype 2/3 infection: a question of low systemic interferon concentrations?

Journal article
Authors Åsa Alsiö
Peer Brehm Christensen
Martti Färkkilä
Nina Langeland
Mads Rauning Buhl
Court Pedersen
Kristine Mørch
Bart L Haagmans
Johan Westin
Kristoffer Hellstrand
Gunnar Norkrans
Martin Lagging
Published in Clinical infectious diseases
Volume 50
Issue 4
Pages e22-e25
ISSN 1537-6591
Publication year 2010
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages e22-e25
Language en
Keywords Adult, Age Factors, Antibodies, blood, Antiviral Agents, administration & dosage, Body Mass Index, Drug Therapy, Combination, Hepacivirus, genetics, Hepatitis C, blood, drug therapy, immunology, virology, Humans, Interferon Alfa-2a, administration & dosage, blood, immunology, Middle Aged, Multivariate Analysis, Polyethylene Glycols, administration & dosage, RNA, Viral, analysis, Ribavirin, administration & dosage, Viral Load
Subject categories Microbiology in the medical area


Twelve of 303 per-protocol patients were nonresponders in a 12-week versus 24-week treatment study of hepatitis C virus (HCV) genotype 2/3 infection. The nonresponders had significantly lower interferon concentrations, as well as significantly greater mean age, body mass index, and viral load. Suboptimal drug concentrations may thus contribute to lack of response to therapy in patients with infection due to HCV genotype 2/3.

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