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Are FoxP3(+) cells involved in hyporesponsiveness to interferon/ribavirin therapy in chronic hepatitis C?

Journal article
Authors Johan Westin
Kristoffer Hellstrand
A P Dhillon
Martin Lagging
Published in Journal of viral hepatitis
Volume 18
Issue 2
Pages 149-151
ISSN 1365-2893
Publication year 2011
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 149-151
Language en
Links dx.doi.org/10.1111/j.1365-2893.2010...
Keywords antiviral treatment; Foxp3; hepatitis C virus; histopathology; immunohistochemistry; regulatory T cells; tregs
Subject categories Microbiology in the medical area

Abstract

Summary. We aimed to clarify the role of liver-infiltrating FoxP3(+)T cells for the response to therapy in chronic hepatitis C. Liver biopsies from 52 patients were collected prior to the start of interferon/ribavirin treatment, and the kinetics of viral decay during treatment were compared in patients with high and low infiltration of FoxP3(+) cells. These groups did not differ with respect to the effectiveness of early viral clearance or the frequency of sustained viral response. Our data imply that FoxP3(+) cell-mediated immunosuppression is not a major mechanism of hyporesponsiveness to interferon-based therapy in chronic hepatitis C.

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