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ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors.

Journal article
Authors Helene Gustavsson
Tajana Tesan
Karin Jennbacken
Kouji Kuno
Jan-Erik Damber
Karin Welén
Published in BMC cancer
Volume 10
Pages 288
ISSN 1471-2407
Publication year 2010
Published at Institute of Clinical Sciences, Department of Urology
Pages 288
Language en
Links dx.doi.org/10.1186/1471-2407-10-288
Keywords ADAM Proteins, genetics, metabolism, Animals, Blood Vessels, enzymology, pathology, Cell Line, Tumor, Cell Proliferation, Humans, Male, Mice, Mice, Inbred BALB C, Mice, Nude, Neoplasm Transplantation, Neovascularization, Pathologic, enzymology, genetics, Pericytes, enzymology, Prostatic Neoplasms, blood supply, enzymology, genetics, RNA Interference, Thrombospondin 1, metabolism, Time Factors, Transfection, Tumor Burden
Subject categories Urology and andrology

Abstract

Decreased expression of the angiogenesis inhibitor ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) has previously been reported during prostate cancer progression. The aim of this study was to investigate the function of ADAMTS1 in prostate tumors.

Page Manager: Webmaster|Last update: 9/11/2012
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