To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Levels of antibody agains… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Levels of antibody against 11 Staphylococcus aureus antigens in a healthy population.

Journal article
Authors Patricia Colque-Navarro
Gunnar Jacobsson
Rune Andersson
Jan-Ingmar Flock
Roland Möllby
Published in Clinical and vaccine immunology : CVI
Volume 17
Issue 7
Pages 1117-23
ISSN 1556-679X
Publication year 2010
Published at Institute of Biomedicine
Pages 1117-23
Language en
Links dx.doi.org/10.1128/CVI.00506-09
Keywords Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Antibodies, Bacterial, analysis, Antigen-Antibody Reactions, Antigens, Bacterial, immunology, Antigens, Surface, immunology, Enzyme-Linked Immunosorbent Assay, Humans, Middle Aged, Staphylococcus aureus, immunology, Young Adult
Subject categories Microbiology in the medical area

Abstract

Serum samples from 151 healthy individuals aged from 15 to 89 years were investigated by enzyme-linked immunosorbent assay (ELISA) for IgG levels against 11 different purified antigens from Staphylococcus aureus. Surface antigens, such as teichoic acid, clumping factors A and B, and bone sialoprotein binding protein, and extracellular proteins, such as alpha-toxin, lipase, enterotoxin A, toxic shock syndrome toxin, scalded-skin syndrome toxin, fibrinogen binding protein, and extracellular adherence protein, were used. The IgG values were analyzed in relation to the state of nasal carriage at the time of sampling. There was great individual variation in antibody levels in both young and elderly healthy subjects. Occurrence of S. aureus in the nares at the time of sampling was correlated with higher antibody levels, while elderly individuals over 65 years of age showed slightly lower levels than younger adults. More individuals than was expected from random probability calculations showed high antibody levels against several antigens, and more individuals than would be expected showed low levels against several antigens. Certain extracellular proteins had more often induced IgG levels of the same magnitude in the same individuals, indicating that among these individuals, there was a tendency to respond to certain antigens in the same way. Most individuals had circulating IgG antibodies to the 11 tested antigens, and some individuals had the tendency to be "good responders" to several antigens, while others were "poor responders." These findings constitute basic knowledge for the development of improved serological diagnostics, immune prophylaxis, individual prognosis tools, and therapy against invasive Staphylococcus aureus infections.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?