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Light subunit of neurofilament triplet protein in the cerebrospinal fluid after subthalamic nucleus stimulation for Parkinson's disease.

Journal article
Authors Radu Constantinescu
Björn Holmberg
Lars Rosengren
O Corneliusson
Bo Johnels
Henrik Zetterberg
Published in Acta neurologica Scandinavica
Volume 124
Issue 3
Pages 206-10
ISSN 1600-0404
Publication year 2011
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 206-10
Language en
Links dx.doi.org/10.1111/j.1600-0404.2010...
Subject categories Psychiatry

Abstract

Constantinescu R, Holmberg B, Rosengren L, Corneliusson O, Johnels B, Zetterberg H. Light subunit of neurofilament triplet protein in the cerebrospinal fluid after subthalamic nucleus stimulation for Parkinson's disease.
Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2010.01451.x.
© 2010 John Wiley & Sons A/S. Objectives - Cerebrospinal fluid (CSF) levels of neurofilament triplet protein (NFL), a non-specific marker of neuronal damage, are normal in Parkinson's disease (PD) but increased after brain trauma and in several neurological disorders. Using longitudinal CSF-NFL measurements as an indicator of neuronal damage, this study investigated the impact of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on the brain, directly following the surgical intervention and in chronically treated patients with PD. Materials and methods - CSF-NFL levels were measured consecutively in eight patients with PD before and after STN-DBS treatment. Results - CSF-NFL levels were normal prior to STN-DBS and increased sharply during the first 2 weeks post-operatively, but normalized after 12 months or more. Conclusion - The STN-DBS procedure leads to an acute but limited neuronal damage, as expected. However, normal CSF-NFL levels at 12 months post-operatively and beyond suggest the absence of any long-term neuronal damage caused by long-term STN-DBS stimulation.

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