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Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity.

Journal article
Authors Linda A W Verhagen
Emil Egecioglu
Mieneke C M Luijendijk
Jacquelien J G Hillebrand
Roger A. H. Adan
Suzanne L. Dickson
Published in European neuropsychopharmacology
Volume 21
Issue 5
Pages 384-392
ISSN 1873-7862
Publication year 2011
Published at Institute of Neuroscience and Physiology, Department of Physiology
Pages 384-392
Language en
Keywords Ghrelin; GHS-R1A antagonist; Activity-based anorexia; Food anticipatory activity; Running wheel activity; JMV2959
Subject categories Medical and Health Sciences


Using the rodent activity-based anorexia (ABA) model that mimics clinical features of anorexia nervosa that include food restriction-induced hyperlocomotion, we found that plasma ghrelin levels are highly associated with food anticipatory behaviour, measured by running wheel activity in rats. Furthermore, we showed that ghrelin receptor (GHS-R1A) knockout mice do not anticipate food when exposed to the ABA model, unlike their wild type littermate controls. Likewise, food anticipatory activity in the ABA model was suppressed by a GHS-R1A antagonist administered either by acute central (ICV) injection to rats or by chronic peripheral treatment to mice. Interestingly, the GHS-R1A antagonist did not alter food intake in any of these models. Therefore, we hypothesize that suppression of the central ghrelin signaling system via GHS-R1A provides an interesting therapeutic target to treat hyperactivity in patients suffering from anorexia nervosa.

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