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Ghrelin increases intake of rewarding food in rodents.

Journal article
Authors Emil Egecioglu
Elisabeth Jerlhag
Nicolas Salomé
Karolina P Skibicka
David Haage
Mohammad Bohlooly-Yeganeh
Daniel Andersson
Mikael Bjursell
Daniel Perrissoud
Jörgen Engel
Suzanne L. Dickson
Published in Addiction biology
Volume 15
Issue 3
Pages 304-11
ISSN 1369-1600
Publication year 2010
Published at Institute of Neuroscience and Physiology, Department of Physiology
Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 304-11
Language en
Links dx.doi.org/10.1111/j.1369-1600.2010...
https://gup.ub.gu.se/file/114758
Subject categories Physiology

Abstract

We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

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