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Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré

Journal article
Authors Natalia Mossberg
Oluf Andersen
Magnus Nordin
Staffan Nilsson
Åke Svedhem
Tomas Bergström
Kristoffer Hellstrand
Charlotta Movitz
Published in Journal of Inflammation
Volume 7
Pages Art nr. 40
ISSN 1476-9255
Publication year 2010
Published at Institute of Neuroscience and Physiology
Department of Mathematical Sciences, Mathematical Statistics
Institute of Biomedicine
Pages Art nr. 40
Language en
Links dx.doi.org/10.1186/1476-9255-7-40
Keywords oxygen radical production, RGBS, severity
Subject categories Microbiology in the medical area

Abstract

Background: The recurrent Guillain-Barré syndrome (RGBS) is characterized by at least two GBS episodes with intervening remission. In a previous study of monophasic GBS, we reported that the magnitude of oxygen radical production ("respiratory burst”) in peripheral blood leukocytes was inversely correlated to disease severity. The present study sought to establish a similar correlation in patients with RGBS. Methods: Oxygen radical production in leukocytes was induced by formyl-Met-Leu-Phe (fMLF), Trp-Lys-Tyr-Met-Val- Met-NH2 (WKYMVM), or phorbol myristate acetate (PMA) and assessed by quantifying superoxide anion formed by the leukocyte NADPH oxidase. Results: Disease severity, assessed using the MRC score, was negatively correlated to superoxide anion production triggered by fMLF or WKYMVM (p = 0.001 and 0.002, respectively; n = 10). Superoxide anion production also was significantly lower in RGBS patients with incomplete recovery after stimulation with fMLF (p = 0.004) or WKYMVM (p = 0.003). Conclusion: We conclude that a lower respiratory burst in leukocytes is strongly associated with a severe course of RGBS

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