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Cerebrospinal fluid insulin during non-neurological surgery.

Journal article
Authors Sara Bromander
Rolf Anckarsäter
Bo Ahrén
Marianne Kristiansson
Kaj Blennow
Agneta Holmäng
Henrik Zetterberg
Henrik Anckarsäter
Caroline Wass
Published in J Neural Transm (Vienna, Austria:1996)
Volume 117
Issue 10
Pages 1167-70
ISSN 1435-1463
Publication year 2010
Published at Institute of Neuroscience and Physiology, Department of Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 1167-70
Language en
Keywords insulin
Subject categories Physiology, Psychiatry


Insulin plays an important metabolic and transmitter role in the central nervous system, but few studies have investigated the relationship between central and peripheral insulin concentrations. 35 patients undergoing knee surgery had cerebrospinal fluid (CSF) samples drawn before, 3 h after, and in the morning following surgery. Serum insulin concentrations increased after surgery and CSF insulin concentrations changed in the same direction with far smaller amplitude. These results indicate that the blood-brain barrier protects the brain from stress-induced peripheral hormonal fluctuations.

Page Manager: Webmaster|Last update: 9/11/2012

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