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High Education May Offer Protection Against Tauopathy in Patients with Mild Cognitive Impairment.

Journal article
Authors Sindre Rolstad
Arto Nordlund
Carl Eckerström
Marie Gustavsson
Kaj Blennow
Pernille J Olesen
Henrik Zetterberg
Anders Wallin
Published in Journal of Alzheimer's disease : JAD
Volume 21
Issue 1
Pages 221-8
ISSN 1875-8908
Publication year 2010
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 221-8
Language en
Links dx.doi.org/10.3233/JAD-2010-091012
Subject categories Psychiatry

Abstract

The concepts of brain and cognitive reserve stem from the observation that premorbid factors (e.g., education) result in variation in the response to brain pathology. Potential early influence of reserve on pathology, as assessed using the cerebrospinal fluid biomarkers total tau and amyloid-beta{42}, and cognition was explored in mild cognitive impairment (MCI) patients who remained stable over a two-year period. A total of 102 patients with stable MCI grouped on the basis of educational level were compared with regard to biomarker concentrations and cognitive performance. Stable MCI patients with higher education had lower concentrations of t-tau as compared to those with lower education. Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy.

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