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The mouse retina as an angiogenesis model.

Journal article
Authors Andreas Stahl
Kip M Connor
Przemyslaw Sapieha
Jing Chen
Roberta J Dennison
Nathan M Krah
Molly R Seaward
Keirnan L Willett
Christopher M Aderman
Karen I Guerin
Jing Hua
Chatarina Löfqvist
Ann Hellström
Lois E H Smith
Published in Investigative ophthalmology & visual science
Volume 51
Issue 6
Pages 2813-26
ISSN 1552-5783
Publication year 2010
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 2813-26
Language en
Links dx.doi.org/10.1167/iovs.10-5176
Subject categories Medical and Health Sciences

Abstract

The mouse retina has been used extensively over the past decades to study both physiologic and pathologic angiogenesis. Over time, various mouse retina models have evolved into well-characterized and robust tools for in vivo angiogenesis research. This article is a review of the angiogenic development of the mouse retina and a discussion of some of the most widely used vascular disease models. From the multitude of studies performed in the mouse retina, a selection of representative works is discussed in more detail regarding their role in advancing the understanding of both the ocular and general mechanisms of angiogenesis.

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