To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Healing of PTFE grafts in… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Healing of PTFE grafts in a pig model recruit neointimal cells from different sources and do not endothelialize.

Journal article
Authors Stefan Mellander
Per Fogelstrand
K Enocson
Bengt R Johansson
Erney Mattsson
Published in European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Volume 30
Issue 1
Pages 63-70
ISSN 1078-5884
Publication year 2005
Published at Wallenberg Laboratory
Institute of Anatomy and Cell Biology
Pages 63-70
Language en
Keywords Actins, metabolism, Anastomosis, Surgical, Animals, Arterial Occlusive Diseases, metabolism, pathology, surgery, Blood Vessel Prosthesis, Cell Division, Disease Models, Animal, Foreign-Body Reaction, metabolism, pathology, Iliac Artery, metabolism, surgery, ultrastructure, Immunohistochemistry, Leukocyte Count, Leukocytes, ultrastructure, Male, Microscopy, Electron, Scanning, Microscopy, Electron, Transmission, Polytetrafluoroethylene, Proliferating Cell Nuclear Antigen, metabolism, Stents, Swine, Tunica Intima, metabolism, ultrastructure, Wound Healing, physiology, von Willebrand Factor, metabolism
Subject categories Surgery


OBJECTIVES: The aim of this study was to analyze the cellular sources for the neointima and the cell type that is lining the lumen in artificial grafts implanted in pigs. MATERIALS AND METHODS: We used polytetrafluoroethylene grafts as bypasses from the common to the external iliac arteries. The animals were sacrificed after 1, 4, 7, 14, 21, 30, 60 and 90 days. Morphological, immunohistochemical and electron microscope assessments were made. RESULTS: After 7 days a circumferential neoadventitia was formed. At day 14 isolated cellular islets of proliferating cells were observed on the luminal side of the graft without connection to the neoadventitia or the adjacent arteries. In the anastomotic regions at day 14 we observed an isolated neointima in contact with the adjacent artery. The cells lining the lumen had characteristics of both smooth muscle cells and endothelial cells. CONCLUSIONS: Our study suggests that in artificial porcine grafts, the perivascular tissue, the blood and the adjacent artery contribute to the formation of the neointima. The luminal surface is covered by a hybrid cell with both smooth muscle cell and endothelial cell properties.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?