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Filamins in cell signaling, transcription and organ development.

Review article
Authors Xianghua Zhou
John H Hartwig
Levent Akyürek
Published in Trends in Cell Biology
Volume 20
Issue 2
Pages 113-23
ISSN 1879-3088
Publication year 2010
Published at Institute of Biomedicine
Pages 113-23
Language en
Links dx.doi.org/10.1016/j.tcb.2009.12.00...
Keywords filamin; development; cell signaling
Subject categories Cell and Molecular Biology

Abstract

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin filament networks and link them to cellular membranes where they integrate cell architectural and signaling functions important for cell locomotion. Filamins have been shown to bind to proteins with diverse functions and are implicated in human genetic diseases including malformations of the skeleton, brain, and heart. Mouse models of filamin deficiency have advanced our understanding of the important roles filamins play in embryonic development and disease progression. These studies provide clear evidence that cytoskeletal filamin proteins integrate cell signaling, transcription and organ development. This review focuses on the emerging roles of filamins in cell signaling and transcription, with emphasis on cell motility and organ development.

Page Manager: Webmaster|Last update: 9/11/2012
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