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Combination of Hippocampal Volume and Cerebrospinal Fluid Biomarkers Improves Predictive Value in Mild Cognitive Impairment.

Journal article
Authors Carl Eckerström
Ulf Andreasson
Erik Olsson
Sindre Rolstad
Kaj Blennow
Henrik Zetterberg
Helge Malmgren
Åke Edman
Anders Wallin
Published in Dementia and Geriatric Cognitive Disorders
Volume 29
Issue 4
Pages 294-300
ISSN 1421-9824
Publication year 2010
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Biomedicine
Department of Philosophy, Linguistics and Theory of Science
Pages 294-300
Language en
Links dx.doi.org/10.1159/000289814
Keywords Mild cognitive impairment, Hippocampal volume,Cerebrospinal fluid, Beta-Amyloid 42, Total tau
Subject categories Physiology

Abstract

Background: Mild cognitive impairment (MCI) is a heterogeneous condition, and the prognosis differs within the group. Recent findings suggest that hippocampal volumetry and CSF biomarkers can be used to predict which MCI patients have an underlying neurodegenerative disorder. Objective: To examine the combined predictive value of hippocampal volume and CSF levels of total tau (T-tau) and beta-amyloid(42) (Abeta(42)) in stable and converting MCI patients. The participants (n = 68) included patients with MCI at baseline and who converted to dementia by the time of the 2-year follow-up (n = 21), stable MCI patients (n = 21) and healthy controls (n = 26). Methods: The Göteborg MCI study is a clinically based longitudinal study with biannual clinical assessments. Hippocampal volumetry was performed manually, based on data from the 0.5-tesla MRI investigations at baseline. Baseline CSF levels of T-tau and Abeta(42) were measured using commercially available, enzyme-linked immunosorbent assays. Results: The converting MCI group had significantly smaller left hippocampi, lower CSF Abeta(42) and higher T-tau compared to both the stable MCI group and the healthy controls. Multivariate analysis revealed that a combination of the variables outperformed the prognostic ability of the separate variables. Conclusions: Hippocampal volumes supplement the prognostic accuracy of CSF Abeta(42) and T-tau in MCI.

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