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Biodistribution of free 211At and 125I- in nude mice bearing tumors derived from anaplastic thyroid carcinoma cell lines.

Journal article
Authors Charlotta Lundh
Ulrika Lindencrona
Anneli Schmitt
Mikael Nilsson
Eva Forssell-Aronsson
Published in Cancer biotherapy & radiopharmaceuticals
Volume 21
Issue 6
Pages 591-600
ISSN 1084-9785
Publication year 2006
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Institute of Clinical Sciences
Pages 591-600
Language en
Links dx.doi.org/10.1089/cbr.2006.21.591
Keywords Animals, Astatine, blood, pharmacokinetics, Cell Line, Tumor, Female, Health, Humans, Iodine Radioisotopes, blood, pharmacokinetics, Mice, Mice, Inbred BALB C, Mice, Nude, Neoplasm Transplantation, Radiometry, Thyroid Neoplasms, blood, pathology, Xenograft Model Antitumor Assays
Subject categories Radiological physics, Cancer and Oncology

Abstract

Free 211At has been proposed for therapy of anaplastic thyroid carcinoma (ATC). However, no extensive biodistribution study comparing tumor-bearing and nontumor-bearing mice has previously been performed. The aim of this study was to perform a complete evaluation of the biodistribution of 211At, both for normal and ATC-bearing mice. For comparison, the biodistribution of 125I- was simultaneously studied. Dosimetric evaluations were performed to investigate if (211)At can be used for therapy of ATC. METHODS: Athymic nude mice were subcutaneously injected with either of two human ATC cell lines, HTh83 and KAT-4. Tumor-bearing and nontumor-bearing mice were injected intravenously with 0.3 MBq 211At and 0.3 MBq 125I- simultaneously. The mice were sacrificed 4-24 hours after injection, and the activity concentrations in tissues were determined. RESULTS: Except for the thyroid, the concentration of 211At was higher than that of 125I- in the tissues. The uptake of 211At was primarily high in NIS-expressing organs. Furthermore, the absorbed doses to these organs were higher than both tumor types. CONCLUSIONS: The biodistribution of 211At and 125I- differed in this animal model. The higher mean absorbed dose from 211At in several organs than in tumor tissue restricts the possibility of using free 211At for therapy of ATC.

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