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Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids.

Journal article
Authors Louise Olofsson
Bob Olsson
Ted Lystig
Peter Jacobson
Margareta Jernås
Kajsa Sjöholm
Anders Gummesson
Lars Sjöström
Per Eriksson
Anders Hamsten
Laura P Hale
Dag Thelle
Björn Carlsson
Lena M S Carlsson
Published in Metabolism
Volume 59
Issue 9
Pages 1316-1318
ISSN 1532-8600
Publication year 2010
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 1316-1318
Language en
Links dx.doi.org/10.1016/j.metabol.2009.1...
Subject categories Molecular medicine (genetics and pathology)

Abstract

Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol (P = .00088) in healthy subjects and during weight loss (P = .059). The ZAG genotype was associated with total cholesterol (P = .014) and low-density lipoprotein cholesterol (P = .026) in healthy subjects, and the associations were replicated in an additional cohort (P = .0017 and P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism.

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