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Microbial-gut interactions in health and disease. Progress in enteric vaccine development.

Journal article
Authors Ann-Mari Svennerholm
Duncan Steele
Published in Best practice & research. Clinical gastroenterology
Volume 18
Issue 2
Pages 421-45
ISSN 1521-6918
Publication year 2004
Published at Institute of Medical Microbiology/Immunology
Pages 421-45
Language en
Keywords Cholera, complications, prevention & control, Diarrhea, microbiology, prevention & control, virology, Dysentery, Bacillary, complications, prevention & control, Enterobacteriaceae, drug effects, Escherichia coli Infections, complications, prevention & control, Humans, Rotavirus Infections, complications, prevention & control, Typhoid Fever, complications, prevention & control, Vaccines, administration & dosage
Subject categories Microbiology in the medical area


Enteric infections resulting in diarrhoea are among the most important causes of morbidity and mortality, particularly in children in developing countries. They are also a common cause of disease among travellers to Africa, Asia and Latin America. Recently, effective, live and inactivated oral and parenteral vaccines against some of the most severe enteric infections-cholera and typhoid fever-have been licensed in several countries. Different candidate vaccines against rotavirus, Shigella and ETEC diarrhoea have also been developed and tested for safety and immunogenicity in developed as well as in developing countries. The protective efficacy of several of these vaccines has also been tested, either in human volunteer challenge studies or in field trials. In this chapter we describe the properties and availability of the recently licensed vaccines and present an update on the diverse efforts being made to achieve new or improved vaccines against the most prevalent enteropathogens.

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